Anti-HMGA2 antibody (55-109) (STJ24036)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HMGA2 (55-109) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HMGA2 |
| Gene ID | 8091 |
| Uniprot ID | HMGA2_HUMAN |
| Immunogen Region | 55-109 |
| Immunogen Sequence | SKNKSPSKAAQKKAEATGEK RPRGRPRKWPQQVVQKKPAQ EETEETSSQESAEED |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 55-109 of human HMGA2 (NP_003474.1). |
Additional Info
| Post Translational Modifications | Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2. |
| Function | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner. |
| Protein Name | High Mobility Group Protein Hmgi-CHigh Mobility Group At-Hook Protein 2 |
| Database Links | Reactome: R-HSA-2559584 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-High Mobility Group Protein Hmgi-C antibodyAnti-High Mobility Group At-Hook Protein 2 antibodyAnti-HMGA2 antibodyAnti-HMGIC antibody |
Information sourced from Uniprot.org