Anti-HM74 antibody (285-334 aa) (STJ93547)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GPR109 at the amino acid range 285-334
General Information
| Short Description | Rabbit polyclonal anti-Hydroxycarboxylic acid receptor 3 and Hydroxycarboxylic acid receptor 2 (285-334 aa) for use in WB, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HCAR2HCAR3 |
| Gene ID | 3384428843 |
| Uniprot ID | HCAR2_HUMANHCAR3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GPR109 at the amino acid range 285-334 |
| Immunogen Region | 285-334 aa |
| Specificity | HM74 Polyclonal Antibody detects endogenous levels of HM74 protein. |
Additional Info
| Function | Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. |
| Protein Name | Hydroxycarboxylic Acid Receptor 3G-Protein Coupled Receptor 109bG-Protein Coupled Receptor Hm74G-Protein Coupled Receptor Hm74bNiacin Receptor 2Nicotinic Acid Receptor 2 |
| Database Links | Reactome: R-HSA-3296197Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Hydroxycarboxylic Acid Receptor 3 antibodyAnti-G-Protein Coupled Receptor 109b antibodyAnti-G-Protein Coupled Receptor Hm74 antibodyAnti-G-Protein Coupled Receptor Hm74b antibodyAnti-Niacin Receptor 2 antibodyAnti-Nicotinic Acid Receptor 2 antibodyAnti-HCAR3 antibodyAnti-GPR109B antibodyAnti-HCA3 antibodyAnti-HM74B antibodyAnti-NIACR2 antibody |
Information sourced from Uniprot.org