Anti-HLTF antibody [R07-6M2] (STJA0037172)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human HLTF
General Information
| Short Description | Rabbit monoclonal anti-HLTF for use in WB, IHC-P, ICC and IF in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-6M2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HLTF |
| Gene ID | 6596 |
| Uniprot ID | HLTF_HUMAN |
| Immunogen | A synthesized peptide derived from human HLTF |
Additional Info
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. |
| Function | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity.This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. |
| Protein Name | Helicase-Like Transcription FactorDna-Binding Protein/Plasminogen Activator Inhibitor 1 RegulatorHip116Ring Finger Protein 80Ring-Type E3 Ubiquitin Transferase HltfSwi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3Sucrose Nonfermenting Protein 2-Like 3 |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmNuclear Localization Is Stimulated By Progesterone |
| Alternative Antibody Names | Anti-Helicase-Like Transcription Factor antibodyAnti-Dna-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator antibodyAnti-Hip116 antibodyAnti-Ring Finger Protein 80 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Hltf antibodyAnti-Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3 antibodyAnti-Sucrose Nonfermenting Protein 2-Like 3 antibodyAnti-HLTF antibodyAnti-HIP116A antibodyAnti-RNF80 antibodyAnti-SMARCA3 antibodyAnti-SNF2L3 antibodyAnti-ZBU1 antibody |
Information sourced from Uniprot.org