Anti-HLA-DMB antibody (1-100) [S5MR] (STJ11102725)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal HLA-DMB (1-100) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HLA-DMB |
| Gene ID | 3109 |
| Uniprot ID | DMB_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MITFLPLLLGLSLGCTGAGG FVAHVESTCLLDDAGTPKDF TYCISFNKDLLTCWDPEENK MAPCEFGVLNSLANVLSQHL NQKDTLMQRLRNGLQNCATH |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HLA-DMB (P28068). |
Additional Info
| Function | Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. |
| Protein Name | Hla Class Ii Histocompatibility Antigen - Dm Beta ChainMhc Class Ii Antigen DmbReally Interesting New Gene 7 Protein |
| Database Links | Reactome: R-HSA-2132295 |
| Cellular Localisation | Late Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneLocalizes To Late Endocytic CompartmentAssociates With Lysosome Membranes |
| Alternative Antibody Names | Anti-Hla Class Ii Histocompatibility Antigen - Dm Beta Chain antibodyAnti-Mhc Class Ii Antigen Dmb antibodyAnti-Really Interesting New Gene 7 Protein antibodyAnti-HLA-DMB antibodyAnti-DMB antibodyAnti-RING7 antibody |
Information sourced from Uniprot.org