Anti-HK2 antibody [3D3] (STJ98152)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human HXK II expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Hexokinase-2 for use in WB, IHC, IF, FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/FC/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3D3 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IHC 1:200-1:1000FC 1:200-1:400ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HK2 |
| Gene ID | 3099 |
| Uniprot ID | HXK2_HUMAN |
| Immunogen | Purified recombinant fragment of human HXK II expressed in E. Coli. |
| Specificity | HXK II Monoclonal Antibody detects endogenous levels of HXK II protein. |
Additional Info
| Function | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. |
| Protein Name | Hexokinase-2Hexokinase Type IiHk IiHexokinase-BMuscle Form Hexokinase |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | Mitochondrion Outer MembranePeripheral Membrane ProteinCytoplasmCytosolThe Mitochondrial-Binding Peptide (Mbp) Region Promotes Association With The Mitochondrial Outer MembraneThe Interaction With The Mitochondrial Outer Membrane Via The Mitochondrial-Binding Peptide (Mbp) Region Promotes Higher Stability Of The ProteinRelease From The Mitochondrial Outer Membrane Into The Cytosol Induces Permeability Transition Pore (Ptp) Opening And Apoptosis |
| Alternative Antibody Names | Anti-Hexokinase-2 antibodyAnti-Hexokinase Type Ii antibodyAnti-Hk Ii antibodyAnti-Hexokinase-B antibodyAnti-Muscle Form Hexokinase antibodyAnti-HK2 antibody |
Information sourced from Uniprot.org