Anti-HJV/Hemojuvelin antibody [SAA1409] {PerCP} (STJA0030580)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPerCP
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal Hemojuvelin antibody for use in FC in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1409 |
| Isotype | IgG2ak |
| Conjugation | PerCP |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | HJV |
| Gene ID | 148738 |
| Uniprot ID | RGMC_HUMAN |
Additional Info
| Post Translational Modifications | Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis. |
| Function | Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. |
| Protein Name | HemojuvelinHemochromatosis Type 2 ProteinHemojuvelin Bmp CoreceptorRgm Domain Family Member C |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorAlso Released In The Extracellular Space |
| Alternative Antibody Names | Anti-Hemojuvelin antibodyAnti-Hemochromatosis Type 2 Protein antibodyAnti-Hemojuvelin Bmp Coreceptor antibodyAnti-Rgm Domain Family Member C antibodyAnti-HJV antibodyAnti-HFE2 antibodyAnti-RGMC antibody |
Information sourced from Uniprot.org