Anti-HJV/Hemojuvelin antibody [SAA1409] {PerCP} (STJA0030580)

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STJA0030580
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: FC
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Hemojuvelin is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA1409
Conjugation: PerCP
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: HJV
Gene ID: 148738
Uniprot ID: RGMC_HUMAN
Post Translational Modifications Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis.
Function Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Protein Name Hemojuvelin
Hemochromatosis Type 2 Protein
Hemojuvelin Bmp Coreceptor
Rgm Domain Family Member C
Database Links Reactome: R-HSA-373752
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Also Released In The Extracellular Space
Alternative Antibody Names Anti-Hemojuvelin antibody
Anti-Hemochromatosis Type 2 Protein antibody
Anti-Hemojuvelin Bmp Coreceptor antibody
Anti-Rgm Domain Family Member C antibody
Anti-HJV antibody
Anti-HFE2 antibody
Anti-RGMC antibody

Information sourced from Uniprot.org

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