Anti-HJV antibody (270-350 aa) (STJ192361)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 270-350
General Information
| Short Description | Rabbit polyclonal anti-Hemojuvelin (270-350 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HJV |
| Gene ID | 148738 |
| Uniprot ID | RGMC_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 270-350 |
| Immunogen Region | 270-350 aa |
| Specificity | RGMC Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis. |
| Function | Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. |
| Protein Name | HemojuvelinHemochromatosis Type 2 ProteinHemojuvelin Bmp CoreceptorRgm Domain Family Member C |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorAlso Released In The Extracellular Space |
| Alternative Antibody Names | Anti-Hemojuvelin antibodyAnti-Hemochromatosis Type 2 Protein antibodyAnti-Hemojuvelin Bmp Coreceptor antibodyAnti-Rgm Domain Family Member C antibodyAnti-HJV antibodyAnti-HFE2 antibodyAnti-RGMC antibody |
Information sourced from Uniprot.org