| Tissue Specificity | highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung. |
| Function | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. |
| Protein Name | Holliday Junction Recognition Protein14-3-3-Associated Akt SubstrateFetal Liver-Expressing Gene 1 ProteinUp-Regulated In Lung Cancer 9 |
| Database Links | Reactome: R-HSA-606279 |
| Cellular Localisation | NucleusNucleolusChromosomeCentromereLocalizes In Centromeres During Late Telophase And Early G1When Cenpa Nucleosomes Are AssembledLocalizes To Nucleolus During S PhaseNucleolus Site Being Often Related To Storage |
| Alternative Antibody Names | Anti-Holliday Junction Recognition Protein antibodyAnti-14-3-3-Associated Akt Substrate antibodyAnti-Fetal Liver-Expressing Gene 1 Protein antibodyAnti-Up-Regulated In Lung Cancer 9 antibodyAnti-HJURP antibodyAnti-FAKTS antibodyAnti-FLEG1 antibodyAnti-URLC9 antibody |
Information sourced from Uniprot.org
