| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Histone H4 (6-55 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | H4C1.H4C2.H4C3.H4C4.H4C5.H4C6.H4C8.H4C9.H4C11.H4C12.H4C13.H4C14.H4C15.H4C16 |
| Gene ID: | 121504/554313/8294/8359/8360/8361/8362/8363/8364/8365/8366/8367/8368/8370 |
| Uniprot ID: | H4_HUMAN |
| Immunogen Region: | 6-55 aa |
| Specificity: | Histone H4 Polyclonal Antibody detects endogenous levels of Histone H4 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Histone H4 at the amino acid range 6-55 |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Protein Name | Histone H4 |
| Database Links | Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110330 Reactome: R-HSA-110331 Reactome: R-HSA-1221632 Reactome: R-HSA-171306 Reactome: R-HSA-1912408 Reactome: R-HSA-201722 Reactome: R-HSA-212300 Reactome: R-HSA-2299718 Reactome: R-HSA-2559580 Reactome: R-HSA-2559582 Reactome: R-HSA-2559586 Reactome: R-HSA-3214815 Reactome: R-HSA-3214841 Reactome: R-HSA-3214842 Reactome: R-HSA-3214847 Reactome: R-HSA-3214858 Reactome: R-HSA-427359 Reactome: R-HSA-427389 Reactome: R-HSA-427413 Reactome: R-HSA-4551638 Reactome: R-HSA-5250924 Reactome: R-HSA-5334118 Reactome: R-HSA-5578749 Reactome: R-HSA-5617472 Reactome: R-HSA-5625886 Reactome: R-HSA-5693565 Reactome: R-HSA-5693571 Reactome: R-HSA-5693607 Reactome: R-HSA-606279 Reactome: R-HSA-68616 Reactome: R-HSA-69473 Reactome: R-HSA-73728 Reactome: R-HSA-73772 Reactome: R-HSA-8936459 Reactome: R-HSA-8939236 Reactome: R-HSA-9018519 Reactome: R-HSA-912446 Reactome: R-HSA-9609690 Reactome: R-HSA-9610379 Reactome: R-HSA-9616222 Reactome: R-HSA-9670095 Reactome: R-HSA-9710421 Reactome: R-HSA-977225 Reactome: R-HSA-9821002 Reactome: R-HSA-9821993 Reactome: R-HSA-9843940 Reactome: R-HSA-9843970 Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus Chromosome |
| Alternative Antibody Names | Anti-Histone H4 antibody Anti-H4C1 antibody Anti-H4 antibody Anti-A antibody Anti-H4FA antibody Anti-HIST1H4A.H4C2 antibody Anti-H4 antibody Anti-I antibody Anti-H4FI antibody Anti-HIST1H4B.H4C3 antibody Anti-H4 antibody Anti-G antibody Anti-H4FG antibody Anti-HIST1H4C.H4C4 antibody Anti-H4 antibody Anti-B antibody Anti-H4FB antibody Anti-HIST1H4D.H4C5 antibody Anti-H4 antibody Anti-J antibody Anti-H4FJ antibody Anti-HIST1H4E.H4C6 antibody Anti-H4 antibody Anti-C antibody Anti-H4FC antibody Anti-HIST1H4F.H4C8 antibody Anti-H4 antibody Anti-H antibody Anti-H4FH antibody Anti-HIST1H4H.H4C9 antibody Anti-H4 antibody Anti-M antibody Anti-H4FM antibody Anti-HIST1H4I.H4C11 antibody Anti-H4 antibody Anti-E antibody Anti-H4FE antibody Anti-HIST1H4J.H4C12 antibody Anti-H4 antibody Anti-D antibody Anti-H4FD antibody Anti-HIST1H4K.H4C13 antibody Anti-H4 antibody Anti-K antibody Anti-H4FK antibody Anti-HIST1H4L.H4C14 antibody Anti-H4 antibody Anti-N antibody Anti-H4F2 antibody Anti-H4FN antibody Anti-HIST2H4 antibody Anti-HIST2H4A.H4C15 antibody Anti-H4 antibody Anti-O antibody Anti-H4FO antibody Anti-HIST2H4B.H4C16 antibody Anti-H4-16 antibody Anti-HIST4H4 antibody |
Information sourced from Uniprot.org