| Tissue Specificity | Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. |
| Post Translational Modifications | Sumoylated. Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo. |
| Function | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
| Protein Name | Protein HiraTup1-Like Enhancer Of Split Protein 1 |
| Database Links | Reactome: R-HSA-2559584Reactome: R-HSA-9821993 |
| Cellular Localisation | NucleusPml BodyPrimarilyThough Not ExclusivelyLocalized To The NucleusLocalizes To Pml Bodies Immediately Prior To Onset Of Senescence |
| Alternative Antibody Names | Anti-Protein Hira antibodyAnti-Tup1-Like Enhancer Of Split Protein 1 antibodyAnti-HIRA antibodyAnti-DGCR1 antibodyAnti-HIR antibodyAnti-TUPLE1 antibody |
Information sourced from Uniprot.org
