Anti-HIP1 antibody [R09-7O3] (STJA0036686)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human HIP1
General Information
| Short Description | Rabbit monoclonal anti-HIP1 for use in WB, ICC, IF and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-7O3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:30 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HIP1 |
| Gene ID | 3092 |
| Uniprot ID | HIP1_HUMAN |
| Immunogen | A synthesized peptide derived from human HIP1 |
Additional Info
| Tissue Specificity | Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer. |
| Function | Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. |
| Protein Name | Huntingtin-Interacting Protein 1Hip-1Huntingtin-Interacting Protein IHip-I |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmNucleusEndomembrane SystemCytoplasmic VesicleClathrin-Coated Vesicle MembraneShuttles Between Cytoplasm And NucleusNuclear Translocation Can Be Induced By Ar |
| Alternative Antibody Names | Anti-Huntingtin-Interacting Protein 1 antibodyAnti-Hip-1 antibodyAnti-Huntingtin-Interacting Protein I antibodyAnti-Hip-I antibodyAnti-HIP1 antibody |
Information sourced from Uniprot.org