| Tissue Specificity | Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer. |
| Function | Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. |
| Protein Name | Huntingtin-Interacting Protein 1Hip-1Huntingtin-Interacting Protein IHip-I |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmNucleusEndomembrane SystemCytoplasmic VesicleClathrin-Coated Vesicle MembraneShuttles Between Cytoplasm And NucleusNuclear Translocation Can Be Induced By Ar |
| Alternative Antibody Names | Anti-Huntingtin-Interacting Protein 1 antibodyAnti-Hip-1 antibodyAnti-Huntingtin-Interacting Protein I antibodyAnti-Hip-I antibodyAnti-HIP1 antibody |
Information sourced from Uniprot.org
