| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HIBCH |
| Gene ID: | 26275 |
| Uniprot ID: | HIBCH_HUMAN |
| Immunogen Region: | 33-330 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-330 of human HIBCH (NP_055177.2). |
| Immunogen Sequence: | DAAEEVLLEKKGCTGVITLN RPKFLNALTLNMIRQIYPQL KKWEQDPETFLIIIKGAGGK AFCAGGDIRVISEAEKAKQK IAPVFFREEYMLNNAVGSCQ KPYVALIHGITMGGGVGLSV HGQFRVATEKCLFAMPETAI GLFPDVGGGYFLPRLQGKLG YFLALTGFRLKGRDVYRAGI ATHFVDSEKLAMLEEDLLAL KSPSKENIASVLENYHTESK IDRDKSFILEEHMDKINSC |
| Tissue Specificity | Highly expressed in liver and kidney, also detected in heart, muscle and brain (at protein level). Not detected in lung. |
| Function | Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. |
| Protein Name | 3-Hydroxyisobutyryl-Coa Hydrolase - Mitochondrial3-Hydroxyisobutyryl-Coenzyme A HydrolaseHib-Coa HydrolaseHibyl-Coa-H |
| Database Links | Reactome: R-HSA-70895 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-3-Hydroxyisobutyryl-Coa Hydrolase - Mitochondrial antibodyAnti-3-Hydroxyisobutyryl-Coenzyme A Hydrolase antibodyAnti-Hib-Coa Hydrolase antibodyAnti-Hibyl-Coa-H antibodyAnti-HIBCH antibody |
Information sourced from Uniprot.org