| Tissue Specificity | Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs. |
| Function | Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Involved in the regulation of liver cancer cells self-renewal. |
| Protein Name | Hairy/Enhancer-Of-Split Related With Yrpw Motif Protein 1Cardiovascular Helix-Loop-Helix Factor 2Chf-2Class B Basic Helix-Loop-Helix Protein 31Bhlhb31Hes-Related Repressor Protein 1Hairy And Enhancer Of Split-Related Protein 1Hesr-1Hairy-Related Transcription Factor 1Hrt-1Hhrt1 |
| Database Links | Reactome: R-HSA-2122947Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-8940973Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Hairy/Enhancer-Of-Split Related With Yrpw Motif Protein 1 antibodyAnti-Cardiovascular Helix-Loop-Helix Factor 2 antibodyAnti-Chf-2 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 31 antibodyAnti-Bhlhb31 antibodyAnti-Hes-Related Repressor Protein 1 antibodyAnti-Hairy And Enhancer Of Split-Related Protein 1 antibodyAnti-Hesr-1 antibodyAnti-Hairy-Related Transcription Factor 1 antibodyAnti-Hrt-1 antibodyAnti-Hhrt1 antibodyAnti-HEY1 antibodyAnti-BHLHB31 antibodyAnti-CHF2 antibodyAnti-HERP2 antibodyAnti-HESR1 antibodyAnti-HRT1 antibody |
Information sourced from Uniprot.org
