Anti-Hexosaminidase A/HEXA antibody (89-529aa) [AT20F1] (STJA0041656)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2aL
ImmunogenRecombinant human HEXA (89-529aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Hexosaminidase A/HEXA (89-529aa) for use in ELISA, WB and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/FACS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT20F1 |
| Isotype | IgG2aL |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HEXA |
| Gene ID | 3073 |
| Uniprot ID | HEXA_HUMAN |
| Accession Number | NP_000511.1 |
| Immunogen | Recombinant human HEXA (89-529aa) purified from E. coli |
| Immunogen Region | 89-529aa |
Additional Info
| Post Translational Modifications | N-linked glycan at Asn-115 consists of Man(3)-GlcNAc(2) (Probable). N-linked glycan at Asn-157 consists of either GlcNAc or GlcNAc(2)-Man(7-9). N-linked glycan at Asn-295 consists of either GlcNAc, GlcNAc-Fuc, or GlcNAc(2)-Man(4) (Probable). |
| Function | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. |
| Protein Name | Beta-Hexosaminidase Subunit AlphaBeta-N-Acetylhexosaminidase Subunit AlphaHexosaminidase Subunit AN-Acetyl-Beta-Glucosaminidase Subunit Alpha |
| Database Links | Reactome: R-HSA-2022857Reactome: R-HSA-2024101Reactome: R-HSA-2160916Reactome: R-HSA-3656234Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Beta-Hexosaminidase Subunit Alpha antibodyAnti-Beta-N-Acetylhexosaminidase Subunit Alpha antibodyAnti-Hexosaminidase Subunit A antibodyAnti-N-Acetyl-Beta-Glucosaminidase Subunit Alpha antibodyAnti-HEXA antibody |
Information sourced from Uniprot.org