Anti-HERC5 antibody (STJA0007555)

SKU:
STJA0007555

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ISG15--protein ligase HERC5 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HERC5
Gene ID: 51191
Uniprot ID: HERC5_HUMAN
Specificity: This antibody detects endogenous levels of HERC5 at Human
Immunogen: Synthesized peptide derived from human HERC5
Post Translational Modifications ISGylated.
Function Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Mediates ISGylation of the phosphatase PTEN leading to its degradation, thus alleviating its suppression of the PI3K-AKT signaling pathway and promoting the production of cytokines that facilitate bacterial clearance. Interferes with the function of key viral structural proteins such as ebolavirus structural protein VP40 or HIV-1 protein GAG. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence.ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. Promotes parkin/PRKN ubiquitin E3 ligase activity by suppressing the intramolecular interaction that maintains its autoinhibited conformation. (Microbial infection) Functions as an E3 ligase for ISGylation of hepatitis B virus protein X leading to enhanced viral replication due to increased interferon resistance.
Protein Name E3 Isg15--Protein Ligase Herc5
Cyclin-E-Binding Protein 1
Hect Domain And Rcc1-Like Domain-Containing Protein 5
Database Links Reactome: R-HSA-1169408
Reactome: R-HSA-168928
Reactome: R-HSA-936440
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Perinuclear Region
Associated With The Polyribosomes
Probably Via The 60s Subunit
Alternative Antibody Names Anti-E3 Isg15--Protein Ligase Herc5 antibody
Anti-Cyclin-E-Binding Protein 1 antibody
Anti-Hect Domain And Rcc1-Like Domain-Containing Protein 5 antibody
Anti-HERC5 antibody
Anti-CEB1 antibody
Anti-CEBP1 antibody

Information sourced from Uniprot.org

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