| Tissue Specificity | Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels. |
| Post Translational Modifications | ISGylated. |
| Function | Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Mediates ISGylation of the phosphatase PTEN leading to its degradation, thus alleviating its suppression of the PI3K-AKT signaling pathway and promoting the production of cytokines that facilitate bacterial clearance. Interferes with the function of key viral structural proteins such as ebolavirus structural protein VP40 or HIV-1 protein GAG. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence.ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. Promotes parkin/PRKN ubiquitin E3 ligase activity by suppressing the intramolecular interaction that maintains its autoinhibited conformation. (Microbial infection) Functions as an E3 ligase for ISGylation of hepatitis B virus protein X leading to enhanced viral replication due to increased interferon resistance. |
| Protein Name | E3 Isg15--Protein Ligase Herc5Cyclin-E-Binding Protein 1Hect Domain And Rcc1-Like Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-168928Reactome: R-HSA-936440Reactome: R-HSA-983168Reactome: R-HSA-9833110Reactome: R-HSA-9833482 |
| Cellular Localisation | CytoplasmPerinuclear RegionAssociated With The PolyribosomesProbably Via The 60s Subunit |
| Alternative Antibody Names | Anti-E3 Isg15--Protein Ligase Herc5 antibodyAnti-Cyclin-E-Binding Protein 1 antibodyAnti-Hect Domain And Rcc1-Like Domain-Containing Protein 5 antibodyAnti-HERC5 antibodyAnti-CEB1 antibodyAnti-CEBP1 antibody |
Information sourced from Uniprot.org
