| Function | Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. |
| Protein Name | Small Rna 2'-O-MethyltransferaseHen1 Methyltransferase Homolog 1 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis |
| Alternative Antibody Names | Anti-Small Rna 2'-O-Methyltransferase antibodyAnti-Hen1 Methyltransferase Homolog 1 antibodyAnti-HENMT1 antibodyAnti-C1orf59 antibody |
Information sourced from Uniprot.org
