| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Helicase with zinc finger domain 2 (1909-1958 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HELZ2 |
| Gene ID: | 85441 |
| Uniprot ID: | HELZ2_HUMAN |
| Immunogen Region: | 1909-1958 aa |
| Specificity: | PRIC285 Polyclonal Antibody detects endogenous levels of PRIC285 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PRIC285 at the amino acid range 1909-1958 |
| Function | Can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities. Shows a strong preference for pyrimidine over purine residues for its nuclease activity. Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. |
| Protein Name | 3'-5' Exoribonuclease Helz2Atp-Dependent Rna Helicase Pric285Helicase With Zinc Finger 2 - Transcriptional CoactivatorHelicase With Zinc Finger Domain 2Ppar-Alpha-Interacting Complex Protein 285Ppar-Gamma Dna-Binding Domain-Interacting Protein 1Pdip1Ppar-Gamma Dbd-Interacting Protein 1Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 285 Kda Protein |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-381340Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9707564Reactome: R-HSA-9707616 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-3'-5' Exoribonuclease Helz2 antibodyAnti-Atp-Dependent Rna Helicase Pric285 antibodyAnti-Helicase With Zinc Finger 2 - Transcriptional Coactivator antibodyAnti-Helicase With Zinc Finger Domain 2 antibodyAnti-Ppar-Alpha-Interacting Complex Protein 285 antibodyAnti-Ppar-Gamma Dna-Binding Domain-Interacting Protein 1 antibodyAnti-Pdip1 antibodyAnti-Ppar-Gamma Dbd-Interacting Protein 1 antibodyAnti-Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 285 Kda Protein antibodyAnti-HELZ2 antibodyAnti-KIAA1769 antibodyAnti-PRIC285 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and TRMT2A/HTF9C knockout (KO) HeLa cells, using [KO Validated] TRMT2A/HTF9C Rabbit polyclonal antibody (STJ11100863) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89797/358266/STJ11100863_1__40910.1713122607.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TRMT2A/HTF9C knockout (KO) HeLa cells, using [KO Validated] TRMT2A/HTF9C Rabbit polyclonal antibody (STJ11100863) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.")
