| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HDGFRP2 (501-670) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HDGFL2 |
| Gene ID: |
84717 |
| Uniprot ID: |
HDGR2_HUMAN |
| Immunogen Region: |
501-670 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 501-670 of human HDGFRP2 (NP_116020.1). |
| Immunogen Sequence: |
EELGTLQVTSQILQKNTDVV ATLKKIRRYKANKDVMEKAA EVYTRLKSRVLGPKIEAVQK VNKAGMEKEKAEEKLAGEEL AGEEAPQEKAEDKPSTDLSA PVNGEATSQKGESAEDKEHE EGRDSEEGPRCGSSEDLHDV REGPDLDRPGSDRQERERAR GDSEALDEES |
| Tissue Specificity | Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples. |
| Function | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression. |
| Protein Name | Hepatoma-Derived Growth Factor-Related Protein 2Hdgf-Related Protein 2Hrp-2Hepatoma-Derived Growth Factor 2Hdgf-2 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Hepatoma-Derived Growth Factor-Related Protein 2 antibodyAnti-Hdgf-Related Protein 2 antibodyAnti-Hrp-2 antibodyAnti-Hepatoma-Derived Growth Factor 2 antibodyAnti-Hdgf-2 antibodyAnti-HDGFL2 antibodyAnti-HDGF2 antibodyAnti-HDGFRP2 antibodyAnti-HRP2 antibodyAnti-UNQ785 antibodyAnti-PRO1604 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
