• Western blot analysis of the lysates from COLO205 cells using HDAC7 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using HDAC7 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from HUVEC cells, using HDAC7 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Histone deacetylase 7a Polyclonal Antibody

Anti-HDAC7 antibody (901-950 aa) (STJ93513)

SKU:
STJ93513

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Histone deacetylase 7 (901-950 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HDAC7
Gene ID: 51564
Uniprot ID: HDAC7_HUMAN
Immunogen Region: 901-950 aa
Specificity: Histone deacetylase 7a Polyclonal Antibody detects endogenous levels of Histone deacetylase 7a protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human HDAC7 at the amino acid range 901-950
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response.
Protein Name Histone Deacetylase 7
Hd7
Histone Deacetylase 7a
Hd7a
Database Links Reactome: R-HSA-2122947
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-3108214
Reactome: R-HSA-350054
Reactome: R-HSA-8943724
Cellular Localisation Nucleus
Cytoplasm
In The Nucleus
It Associates With Distinct Subnuclear Dot-Like Structures
Shuttles Between The Nucleus And The Cytoplasm
Treatment With Edn1 Results In Shuttling From The Nucleus To The Perinuclear Region
The Export To Cytoplasm Depends On The Interaction With The 14-3-3 Protein Ywhae And Is Due To Its Phosphorylation
Alternative Antibody Names Anti-Histone Deacetylase 7 antibody
Anti-Hd7 antibody
Anti-Histone Deacetylase 7a antibody
Anti-Hd7a antibody
Anti-HDAC7 antibody
Anti-HDAC7A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance