Anti-HCN2 antibody (491-540 aa) (STJ93476)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human HCN2 at the amino acid range 491-540
General Information
| Short Description | Rabbit polyclonal anti-Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (491-540 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagent |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HCN2 |
| Gene ID | 610 |
| Uniprot ID | HCN2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human HCN2 at the amino acid range 491-540 |
| Immunogen Region | 491-540 aa |
| Specificity | HCN2 Polyclonal Antibody detects endogenous levels of HCN2 protein. |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. S-palmitoylated. N-glycosylated.required for cell surface trafficking of HCN2. |
| Function | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Involved in the initiation of neuropathic pain in sensory neurons. |
| Protein Name | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2Brain Cyclic Nucleotide-Gated Channel 2Bcng-2 |
| Database Links | Reactome: R-HSA-1296061 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Brain Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Bcng-2 antibodyAnti-HCN2 antibodyAnti-BCNG2 antibody |
Information sourced from Uniprot.org