| Tissue Specificity | Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. |
| Post Translational Modifications | Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis. |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. May play a role in kidney injury and repair. (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. TIM1 and Dengue virus are co-internalized during virus entry. (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. (Microbial infection) Plays a positive role in Chikungunya virus cell entry. |
| Protein Name | Hepatitis A Virus Cellular Receptor 1Havcr-1Kidney Injury Molecule 1Kim-1T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1Timd-1T-Cell Immunoglobulin Mucin Receptor 1TimTim-1T-Cell Membrane Protein 1Cd Antigen Cd365 |
| Database Links | Reactome: R-HSA-9694614 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hepatitis A Virus Cellular Receptor 1 antibodyAnti-Havcr-1 antibodyAnti-Kidney Injury Molecule 1 antibodyAnti-Kim-1 antibodyAnti-T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibodyAnti-Timd-1 antibodyAnti-T-Cell Immunoglobulin Mucin Receptor 1 antibodyAnti-Tim antibodyAnti-Tim-1 antibodyAnti-T-Cell Membrane Protein 1 antibodyAnti-Cd Antigen Cd365 antibodyAnti-HAVCR1 antibodyAnti-KIM1 antibodyAnti-TIM1 antibodyAnti-TIMD1 antibody |
Information sourced from Uniprot.org
