| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HAS1 |
| Gene ID: | 3036 |
| Uniprot ID: | HYAS1_HUMAN |
| Immunogen Region: | 80-390 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-390 of human HAS1 (NP_001514.2). |
| Immunogen Sequence: | RVAAAARGPLDAATARSVAL TISAYQEDPAYLRQCLASAR ALLYPRARLRVLMVVDGNRA EDLYMVDMFREVFADEDPAT YVWDGNYHQPWEPAAAGAVG AGAYREVEAEDPGRLAVEAL VRTRRCVCVAQRWGGKREVM YTAFKALGDSVDYVQVCDSD TRLDPMALLELVRVLDEDPR VGAVGGDVRILNPLDSWVSF LSSLRYWVAFNVERACQSYF HCVSCISGPLGLYRNNLLQ |
| Tissue Specificity | Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine. |
| Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate. |
| Protein Name | Hyaluronan Synthase 1Hyaluronate Synthase 1Hyaluronic Acid Synthase 1Ha Synthase 1Huhas1 |
| Database Links | Reactome: R-HSA-2142850 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Hyaluronan Synthase 1 antibodyAnti-Hyaluronate Synthase 1 antibodyAnti-Hyaluronic Acid Synthase 1 antibodyAnti-Ha Synthase 1 antibodyAnti-Huhas1 antibodyAnti-HAS1 antibodyAnti-HAS antibody |
Information sourced from Uniprot.org