• Western blot analysis of 1) Mouse Liver Tissue, 2) Rat Liver Tissue using HAO1 Polyclonal Antibody. Secondary antibody (STJ99666) was diluted at 1:20000
  • Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Anti-HAO1 antibody (STJ197373)

SKU:
STJ197373

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-2-Hydroxyacid oxidase 1 is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS pH7.4, 0.5% BSA, 0.02% Sodium Azide and 50% Glycerol.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range: WB 1:2000-5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HAO1
Gene ID: 54363
Uniprot ID: HAOX1_HUMAN
Specificity: The antibody detects endogenous HAO1 protein.
Immunogen: Recombinant Protein of HAO1
Function Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate. The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine.this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones. Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on L-lactate and 2-hydroxybutanoate.
Protein Name 2-Hydroxyacid Oxidase 1
Haox1
Glycolate Oxidase
Go
Gox
Glyoxylate Oxidase
Database Links Reactome: R-HSA-389661
Reactome: R-HSA-9033241
Cellular Localisation Peroxisome Matrix
Alternative Antibody Names Anti-2-Hydroxyacid Oxidase 1 antibody
Anti-Haox1 antibody
Anti-Glycolate Oxidase antibody
Anti-Go antibody
Anti-Gox antibody
Anti-Glyoxylate Oxidase antibody
Anti-HAO1 antibody
Anti-GOX1 antibody

Information sourced from Uniprot.org

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