Anti-HAMP antibody (STJA0009787)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Hepcidin-25
General Information
| Short Description | Rabbit polyclonal anti-Hepcidin for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HAMP |
| Gene ID | 57817 |
| Uniprot ID | HEPC_HUMAN |
| Immunogen | Synthesized peptide derived from human Hepcidin-25 |
| Specificity | This antibody detects endogenous levels of Hepcidin-25 at Human, Mouse, Rat |
Additional Info
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa. |
| Protein Name | HepcidinLiver-Expressed Antimicrobial Peptide 1Leap-1Putative Liver Tumor RegressorPltr Cleaved Into - Hepcidin-25Hepc25 - Hepcidin-20Hepc20 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Hepcidin antibodyAnti-Liver-Expressed Antimicrobial Peptide 1 antibodyAnti-Leap-1 antibodyAnti-Putative Liver Tumor Regressor antibodyAnti-Pltr Cleaved Into - Hepcidin-25 antibodyAnti-Hepc25 - Hepcidin-20 antibodyAnti-Hepc20 antibodyAnti-HAMP antibodyAnti-HEPC antibodyAnti-LEAP1 antibodyAnti-UNQ487 antibodyAnti-PRO1003 antibody |
Information sourced from Uniprot.org