Anti-H1-6 antibody (STJA0007607)

SKU:
STJA0007607
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Histone H1t is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: H1-6
Gene ID: 3010
Uniprot ID: H1T_HUMAN
Specificity: This antibody detects endogenous levels of HIST1H1T at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human HIST1H1T
Post Translational Modifications Phosphorylated in early spermatids. Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
Function Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).
Protein Name Histone H1t
Testicular H1 Histone
Cellular Localisation Nucleus
Chromosome
Alternative Antibody Names Anti-Histone H1t antibody
Anti-Testicular H1 Histone antibody
Anti-H1-6 antibody
Anti-H1FT antibody
Anti-H1T antibody
Anti-HIST1H1T antibody

Information sourced from Uniprot.org

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