| Function | Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine. |
| Protein Name | Guanylate KinaseGmp KinaseGuanylate Kinase 1 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-9748787 |
| Cellular Localisation | Photoreceptor Inner SegmentCytoplasmCytosolColocalizes With Rd3 In Photoreceptor Inner Segments And To A Lesser Extent In The Outer Plexiform LayerIsoform 2: Mitochondrion |
| Alternative Antibody Names | Anti-Guanylate Kinase antibodyAnti-Gmp Kinase antibodyAnti-Guanylate Kinase 1 antibodyAnti-GUK1 antibodyAnti-GMK antibodyAnti-GMPK antibody |
Information sourced from Uniprot.org
