| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GUK1 |
| Gene ID: | 2987 |
| Uniprot ID: | KGUA_HUMAN |
| Immunogen Region: | 1-197 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human GUK1 (NP_000849.1). |
| Immunogen Sequence: | MSGPRPVVLSGPSGAGKSTL LKRLLQEHSGIFGFSVSHTT RNPRPGEENGKDYYFVTREV MQRDIAAGDFIEHAEFSGNL YGTSKVAVQAVQAMNRICVL DVDLQGVRNIKATDLRPIYI SVQPPSLHVLEQRLRQRNTE TEESLVKRLAAAQADMESSK EPGLFDVVIINDSLDQAYAE LKEALSEEIKKAQRTGA |
| Tissue Specificity | Widely expressed. |
| Function | Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine. |
| Protein Name | Guanylate KinaseGmp KinaseGuanylate Kinase 1 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-9748787 |
| Cellular Localisation | Photoreceptor Inner SegmentCytoplasmCytosolColocalizes With Rd3 In Photoreceptor Inner Segments And To A Lesser Extent In The Outer Plexiform Layer |
| Alternative Antibody Names | Anti-Guanylate Kinase antibodyAnti-Gmp Kinase antibodyAnti-Guanylate Kinase 1 antibodyAnti-GUK1 antibodyAnti-GMK antibodyAnti-GMPK antibody |
Information sourced from Uniprot.org