Anti-GUCY2F antibody (250-460) (STJ116455)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GUCY2F (250-460) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GUCY2F |
| Gene ID | 2986 |
| Uniprot ID | GUC2F_HUMAN |
| Immunogen Region | 250-460 |
| Immunogen Sequence | HSALIGGETQMHLLECAHDL KMTDGTYVFVPYDALLYSLP YKHTPYRVLRNNPKLREAYD AVLTITVESQEKTFYQAFTE AAARGEIPEKLEFDQVSPLF GTIYNSIYFIAQAMNNAMKE NGQAGAASLVQHSRNMQFHG FNQLMRTDSNGNGISEYVIL DTNLKEWELHSTYTVDMEME LLRFGGTPIHFPGGRPPRAD AKCWFAEGKIC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 250-460 of human GUCY2F (NP_001513.2). |
Additional Info
| Tissue Specificity | Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells. |
| Post Translational Modifications | There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. |
| Function | Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane. |
| Protein Name | Retinal Guanylyl Cyclase 2Retgc-2Guanylate Cyclase 2f - RetinalGuanylate Cyclase FGc-FRod Outer Segment Membrane Guanylate Cyclase 2Ros-Gc2 |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | Photoreceptor Outer Segment MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Retinal Guanylyl Cyclase 2 antibodyAnti-Retgc-2 antibodyAnti-Guanylate Cyclase 2f - Retinal antibodyAnti-Guanylate Cyclase F antibodyAnti-Gc-F antibodyAnti-Rod Outer Segment Membrane Guanylate Cyclase 2 antibodyAnti-Ros-Gc2 antibodyAnti-GUCY2F antibodyAnti-GUC2F antibodyAnti-RETGC2 antibody |
Information sourced from Uniprot.org