| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GTF2IRD1 |
| Gene ID: | 9569 |
| Uniprot ID: | GT2D1_HUMAN |
| Immunogen Region: | 660-959 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 660-959 of human GTF2IRD1 (NP_057412.1). |
| Immunogen Sequence: | SLGFSPPALPPERDSGDPLV DESLKRQGFQENYDARLSRI DIANTLREQVQDLFNKKYGE ALGIKYPVQVPYKRIKSNPG SVIIEGLPPGIPFRKPCTFG SQNLERILAVADKIKFTVTR PFQGLIPKPDEDDANRLGEK VILREQVKELFNEKYGEALG LNRPVLVPYKLIRDSPDAVE VTGLPDDIPFRNPNTYDIHR LEKILKAREHVRMVIINQLQ PFAEICNDAKVPAKDSSIP |
| Tissue Specificity | Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested. |
| Function | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8. |
| Protein Name | General Transcription Factor Ii-I Repeat Domain-Containing Protein 1 Gtf2i Repeat Domain-Containing Protein 1 General Transcription Factor Iii Mustrd1/Ben Muscle Tfii-I Repeat Domain-Containing Protein 1 Slow-Muscle-Fiber Enhancer-Binding Protein Use B1-Binding Protein Williams-Beuren Syndrome Chromosomal Region 11 Protein Williams-Beuren Syndrome Chromosomal Region 12 Protein |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-General Transcription Factor Ii-I Repeat Domain-Containing Protein 1 antibody Anti-Gtf2i Repeat Domain-Containing Protein 1 antibody Anti-General Transcription Factor Iii antibody Anti-Mustrd1/Ben antibody Anti-Muscle Tfii-I Repeat Domain-Containing Protein 1 antibody Anti-Slow-Muscle-Fiber Enhancer-Binding Protein antibody Anti-Use B1-Binding Protein antibody Anti-Williams-Beuren Syndrome Chromosomal Region 11 Protein antibody Anti-Williams-Beuren Syndrome Chromosomal Region 12 Protein antibody Anti-GTF2IRD1 antibody Anti-CREAM1 antibody Anti-GTF3 antibody Anti-MUSTRD1 antibody Anti-RBAP2 antibody Anti-WBSCR11 antibody Anti-WBSCR12 antibody |
Information sourced from Uniprot.org