| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | GTF2H5 |
| Gene ID: | 404672 |
| Uniprot ID: | TF2H5_HUMAN |
| Immunogen Region: | 1-71 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-71 of human GTF2H5 (NP_997001.1). |
| Immunogen Sequence: | MVNVLKGVLIECDPAMKQFL LYLDESNALGKKFIIQDIDD THVFVIAELVNVLQERVGEL MDQNAFSLTQK |
| Function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. |
| Protein Name | General Transcription Factor Iih Subunit 5General Transcription Factor Iih Polypeptide 5Tfb5 OrthologTfiih Basal Transcription Factor Complex Ttd-A SubunitTfiih Subunit P8 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167246Reactome: R-HSA-427413Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-674695Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-6796648Reactome: R-HSA-72086Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-73863Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-77075 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-General Transcription Factor Iih Subunit 5 antibodyAnti-General Transcription Factor Iih Polypeptide 5 antibodyAnti-Tfb5 Ortholog antibodyAnti-Tfiih Basal Transcription Factor Complex Ttd-A Subunit antibodyAnti-Tfiih Subunit P8 antibodyAnti-GTF2H5 antibodyAnti-C6orf175 antibodyAnti-TTDA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
