| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-GTF2H4 (1-300) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GTF2H4 |
| Gene ID: | 2968 |
| Uniprot ID: | TF2H4_HUMAN |
| Immunogen Region: | 1-300 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GTF2H4 (NP_001508.1). |
| Immunogen Sequence: | MESTPSRGLNRVHLQCRNLQ EFLGGLSPGVLDRLYGHPAT CLAVFRELPSLAKNWVMRML FLEQPLPQAAVALWVKKEFS KAQEESTGLLSGLRIWHTQL LPGGLQGLILNPIFRQNLRI ALLGGGKAWSDDTSQLGPDK HARDVPSLDKYAEERWEVVL HFMVGSPSAAVSQDLAQLLS QAGLMKSTEPGEPPCITSAG FQFLLLDTPAQLWYFMLQYL QTAQSRGMDLVEILSFLFQ |
| Function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
| Protein Name | General Transcription Factor Iih Subunit 4Basic Transcription Factor 2 52 Kda SubunitBtf2 P52General Transcription Factor Iih Polypeptide 4Tfiih Basal Transcription Factor Complex P52 Subunit |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167246Reactome: R-HSA-427413Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-674695Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-6796648Reactome: R-HSA-72086Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-73863Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-77075 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-General Transcription Factor Iih Subunit 4 antibodyAnti-Basic Transcription Factor 2 52 Kda Subunit antibodyAnti-Btf2 P52 antibodyAnti-General Transcription Factor Iih Polypeptide 4 antibodyAnti-Tfiih Basal Transcription Factor Complex P52 Subunit antibodyAnti-GTF2H4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
