| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GSS |
| Gene ID: | 2937 |
| Uniprot ID: | GSHB_HUMAN |
| Immunogen Region: | 250-474 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-474 of human Glutathione Synthetase (GSS) (NP_000169.1). |
| Immunogen Sequence: | QDRRLFVDGQEIAVVYFRDG YMPRQYSLQNWEARLLLERS HAAKCPDIATQLAGTKKVQQ ELSRPGMLEMLLPGQPEAVA RLRATFAGLYSLDVGEEGDQ AIAEALAAPSRFVLKPQREG GGNNLYGEEMVQALKQLKDS EERASYILMEKIEPEPFENC LLRPGSPARVVQCISELGIF GVYVRQEKTLVMNKHVGHLL RTKAIEHADGGVAAGVAVLD NPYPV |
| Function | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes. |
| Protein Name | Glutathione Synthetase Gsh Synthetase Gsh-S Glutathione Synthase |
| Database Links | Reactome: R-HSA-174403 Reactome: R-HSA-5579006 |
| Alternative Antibody Names | Anti-Glutathione Synthetase antibody Anti-Gsh Synthetase antibody Anti-Gsh-S antibody Anti-Glutathione Synthase antibody Anti-GSS antibody |
Information sourced from Uniprot.org