Post Translational Modifications | Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids. |
Function | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. |
Protein Name | GelsolinAgelActin-Depolymerizing FactorAdfBrevin |
Database Links | Reactome: R-HSA-264870Reactome: R-HSA-6798695Reactome: R-HSA-9662361Reactome: R-HSA-977225 |
Cellular Localisation | Isoform 2: CytoplasmCytoskeletonIsoform 1: Secreted |
Alternative Nanobody Names | Anti-Gelsolin nanobodyAnti-Agel nanobodyAnti-Actin-Depolymerizing Factor nanobodyAnti-Adf nanobodyAnti-Brevin nanobodyAnti-GSN nanobody |
Information sourced from Uniprot.org