Anti-GSKIP antibody (STJA0004842)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human GSKIP
General Information
| Short Description | Rabbit polyclonal anti-Gsk3b-Interacting Protein for use in IHC and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.96 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:40-1:200 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | GSKIP |
| Gene ID | 51527 |
| Uniprot ID | GSKIP_HUMAN |
| Immunogen | Fusion protein of human GSKIP |
Additional Info
| Tissue Specificity | Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas. |
| Post Translational Modifications | Phosphorylated by GSK3B. |
| Function | A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation.while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression. |
| Protein Name | Gsk3b-Interacting ProteinGskipGsk3beta Interaction Protein |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Gsk3b-Interacting Protein antibodyAnti-Gskip antibodyAnti-Gsk3beta Interaction Protein antibodyAnti-GSKIP antibodyAnti-C14orf129 antibodyAnti-HSPC210 antibody |
Information sourced from Uniprot.org