Anti-GRPR antibody (235-384) (STJ23875)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GRPR (235-384) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRPR |
| Gene ID | 2925 |
| Uniprot ID | GRPR_HUMAN |
| Immunogen Region | 235-384 |
| Immunogen Sequence | KNLIQSAYNLPVEGNIHVKK QIESRKRLAKTVLVFVGLFA FCWLPNHVIYLYRSYHYSEV DTSMLHFVTSICARLLAFTN SCVNPFALYLLSKSFRKQFN TQLLCCQPGLIIRSHSTGRS TTCMTSLKSTNPSVATFSLI NGNICHERYV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1). |
Additional Info
| Tissue Specificity | Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain. In brain, expressed in cells throughout the cortex. |
| Function | Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear. In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories. Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity. |
| Protein Name | Gastrin-Releasing Peptide ReceptorGrp-RGrp-Preferring Bombesin Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Gastrin-Releasing Peptide Receptor antibodyAnti-Grp-R antibodyAnti-Grp-Preferring Bombesin Receptor antibodyAnti-GRPR antibody |
Information sourced from Uniprot.org