| Function | Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion.the translocation process is mediated by the cargo receptor TMED10. |
| Protein Name | Endoplasmin94 Kda Glucose-Regulated ProteinGrp-94Heat Shock Protein 90 Kda Beta Member 1Heat Shock Protein Family C Member 4Tumor Rejection Antigen 1Gp96 Homolog |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-3000480Reactome: R-HSA-381183Reactome: R-HSA-381426Reactome: R-HSA-6785807Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum LumenSarcoplasmic Reticulum LumenMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Endoplasmin antibodyAnti-94 Kda Glucose-Regulated Protein antibodyAnti-Grp-94 antibodyAnti-Heat Shock Protein 90 Kda Beta Member 1 antibodyAnti-Heat Shock Protein Family C Member 4 antibodyAnti-Tumor Rejection Antigen 1 antibodyAnti-Gp96 Homolog antibodyAnti-HSP90B1 antibodyAnti-GRP94 antibodyAnti-HSPC4 antibodyAnti-TRA1 antibody |
Information sourced from Uniprot.org
