| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Metabotropic glutamate receptor 6 (828-877 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRM6 |
| Gene ID: | 2916 |
| Uniprot ID: | GRM6_HUMAN |
| Immunogen Region: | 828-877 aa |
| Specificity: | mGluR-6 Polyclonal Antibody detects endogenous levels of mGluR-6 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human mGluR6 at the amino acid range 828-877 |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. |
| Protein Name | Metabotropic Glutamate Receptor 6Mglur6 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus MembraneCell ProjectionDendriteSubject To Trafficking From The Endoplasmic Reticulum To The Golgi Apparatus And Then To The Cell Membrane |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 6 antibodyAnti-Mglur6 antibodyAnti-GRM6 antibodyAnti-GPRC1F antibodyAnti-MGLUR6 antibody |
Information sourced from Uniprot.org
