| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRM1 |
| Gene ID: | 2911 |
| Uniprot ID: | GRM1_HUMAN |
| Immunogen Region: | 920-1140 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 920-1140 of human GRM1 (NP_001264993.1). |
| Immunogen Sequence: | NETACNQTAVIKPLTKSYQG SGKSLTFSDTSTKTLYNVEE EEDAQPIRFSPPGSPSMVVH RRVPSAATTPPLPSHLTAEE TPLFLAEPALPKGLPPPLQQ QQQPPPQQKSLMDQLQGVVS NFSTAIPDFHAVLAGPGGPG NGLRSLYPPPPPPQHLQMLP LQLSTFGEELVSPPADDDDD SERFKLLQEYVYEHEREGNT EEDELEEEEEDLQAASKLTP D |
| Tissue Specificity | Detected in brain. |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. May function in the light response in the retina. Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively. |
| Protein Name | Metabotropic Glutamate Receptor 1Mglur1 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-420499Reactome: R-HSA-6794361Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 1 antibodyAnti-Mglur1 antibodyAnti-GRM1 antibodyAnti-GPRC1A antibodyAnti-MGLUR1 antibody |
Information sourced from Uniprot.org
