Anti-GRK2 antibody [R01-6I5] (STJA0035212)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human GRK2
General Information
| Short Description | Rabbit monoclonal anti-GRK2 for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-6I5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | GRK2 |
| Gene ID | 156 |
| Uniprot ID | ARBK1_HUMAN |
| Immunogen | A synthetic peptide of human GRK2 |
Additional Info
| Tissue Specificity | Expressed in peripheral blood leukocytes. |
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light. |
| Protein Name | Beta-Adrenergic Receptor Kinase 1Beta-Ark-1G-Protein Coupled Receptor Kinase 2 |
| Database Links | Reactome: R-HSA-111933Reactome: R-HSA-416476Reactome: R-HSA-418555Reactome: R-HSA-5635838Reactome: R-HSA-8856825 |
| Cellular Localisation | CytoplasmCell MembranePostsynapsePresynapse |
| Alternative Antibody Names | Anti-Beta-Adrenergic Receptor Kinase 1 antibodyAnti-Beta-Ark-1 antibodyAnti-G-Protein Coupled Receptor Kinase 2 antibodyAnti-GRK2 antibodyAnti-ADRBK1 antibodyAnti-BARK antibodyAnti-BARK1 antibody |
Information sourced from Uniprot.org