• Anti-GRK2 antibody [3F8] (STJ98116)
  • Immunohistochemistry analysis of paraffin-embedded endometrial cancer tissues (left) and cervical cancer tissues (right) with DAB staining using GRK 2 monoclonal antibody.
  • Immunofluorescence analysis of NIH/3T3 cells using GRK 2 monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
  • Western blot analysis using GRK 2 monoclonal antibody against HeLa (1) , Jurkat (2) , MOLT4 (3) , RAJI (4) , THP-1 (5) , L1210 (6) , Cos7 (7) , PC-12 (8) , and NIH/3T3 (9) cell lysate.

Anti-GRK2 antibody [3F8] (STJ98116)

SKU:
STJ98116

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Beta-adrenergic receptor kinase 1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Monoclonal
Clone ID: 3F8
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRK2
Gene ID: 156
Uniprot ID: ARBK1_HUMAN
Specificity: GRK 2 Monoclonal Antibody detects endogenous levels of GRK 2 protein.
Immunogen: Purified recombinant fragment of human GRK 2 expressed in E. Coli.
Function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light.
Protein Name Beta-Adrenergic Receptor Kinase 1
Beta-Ark-1
G-Protein Coupled Receptor Kinase 2
Database Links Reactome: R-HSA-111933
Reactome: R-HSA-416476
Reactome: R-HSA-418555
Reactome: R-HSA-5635838
Reactome: R-HSA-8856825
Cellular Localisation Cytoplasm
Cell Membrane
Postsynapse
Presynapse
Alternative Antibody Names Anti-Beta-Adrenergic Receptor Kinase 1 antibody
Anti-Beta-Ark-1 antibody
Anti-G-Protein Coupled Receptor Kinase 2 antibody
Anti-GRK2 antibody
Anti-ADRBK1 antibody
Anti-BARK antibody
Anti-BARK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance