| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRIN2C |
| Gene ID: |
2905 |
| Uniprot ID: |
NMDE3_HUMAN |
| Immunogen Region: |
20-350 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-350 of human GRIN2C (NP_000826.2). |
| Immunogen Sequence: |
GLGPGQGEQGMTVAVVFSSS GPPQAQFRARLTPQSFLDLP LEIQPLTVGVNTTNPSSLLT QICGLLGAAHVHGIVFEDNV DTEAVAQILDFISSQTHVPI LSISGGSAVVLTPKEPGSAF LQLGVSLEQQLQVLFKVLEE YDWSAFAVITSLHPGHALFL EGVRAVADASHVSWRLLDVV TLELGPGGPRARTQRLLRQL DAPVFVAYCSREEAEVLFAE AAQAGLVGPGHVWLVPNLA |
| Tissue Specificity | Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas. |
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2cGlun2cGlutamate Nmda Receptor Subunit Epsilon-3N-Methyl D-Aspartate Receptor Subtype 2cNmdar2cNr2c |
| Database Links | Reactome: R-HSA-438066Reactome: R-HSA-6794361Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 2c antibodyAnti-Glun2c antibodyAnti-Glutamate Nmda Receptor Subunit Epsilon-3 antibodyAnti-N-Methyl D-Aspartate Receptor Subtype 2c antibodyAnti-Nmdar2c antibodyAnti-Nr2c antibodyAnti-GRIN2C antibodyAnti-NMDAR2C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
