Anti-GRIM19 antibody [R01-3W7] (STJA0036935)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human GRIM19
General Information
| Short Description | Rabbit monoclonal anti-GRIM19 for use in WB, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-3W7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NDUFA13 |
| Gene ID | 51079 |
| Uniprot ID | NDUAD_HUMAN |
| Immunogen | A synthesized peptide derived from human GRIM19 |
Additional Info
| Tissue Specificity | Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. |
| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. |
| Protein Name | Nadh Dehydrogenase Ubiquinone 1 Alpha Subcomplex Subunit 13Cell Death Regulatory Protein Grim-19Complex I-B16.6Ci-B16.6Gene Associated With Retinoic And Interferon-Induced Mortality 19 ProteinGrim-19Gene Associated With Retinoic And Ifn-Induced Mortality 19 ProteinNadh-Ubiquinone Oxidoreductase B16.6 Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-6799198Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinMatrix SideNucleusLocalizes Mainly In The MitochondrionMay Be Translocated Into The Nucleus Upon Ifn/Ra Treatment |
| Alternative Antibody Names | Anti-Nadh Dehydrogenase Ubiquinone 1 Alpha Subcomplex Subunit 13 antibodyAnti-Cell Death Regulatory Protein Grim-19 antibodyAnti-Complex I-B16.6 antibodyAnti-Ci-B16.6 antibodyAnti-Gene Associated With Retinoic And Interferon-Induced Mortality 19 Protein antibodyAnti-Grim-19 antibodyAnti-Gene Associated With Retinoic And Ifn-Induced Mortality 19 Protein antibodyAnti-Nadh-Ubiquinone Oxidoreductase B16.6 Subunit antibodyAnti-NDUFA13 antibodyAnti-GRIM19 antibodyAnti-CDA016 antibodyAnti-CGI-39 antibody |
Information sourced from Uniprot.org