| Function | Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Instead, forms trans-synaptic adhesion complexes with presynaptic neurexins and cerebellins, regulating NMDA and AMPA receptor activity and influencing synaptic plasticity through signal transduction. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel can be triggered by GRM1 in dopaminergic neurons. Also acts as a receptor for GABA, modulating inhibitory synaptic plasticity through non-ionotropic mechanisms. |
| Protein Name | Glutamate Receptor Ionotropic - Delta-1Glud1Glur Delta-1 Subunit |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Delta-1 antibodyAnti-Glud1 antibodyAnti-Glur Delta-1 Subunit antibodyAnti-GRID1 antibodyAnti-KIAA1220 antibody |
Information sourced from Uniprot.org
