| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRID1 |
| Gene ID: | 2894 |
| Uniprot ID: | GRID1_HUMAN |
| Immunogen Region: | 880-1009 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 880-1009 of human GRID1 (NP_060021.1). |
| Immunogen Sequence: | MNSLMDEDIAHKQISPASIE LSALEMGGLAPTQTLEPTRE YQNTQLSVSTFLPEQSSHGT SRTLSSGPSSNLPLPLSSSA TMPSMQCKHRSPNGGLFRQS PVKTPIPMSFQPVPGGVLPE ALDTSHGTSI |
| Function | Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Instead, forms trans-synaptic adhesion complexes with presynaptic neurexins and cerebellins, regulating NMDA and AMPA receptor activity and influencing synaptic plasticity through signal transduction. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel can be triggered by GRM1 in dopaminergic neurons. Also acts as a receptor for GABA, modulating inhibitory synaptic plasticity through non-ionotropic mechanisms. |
| Protein Name | Glutamate Receptor Ionotropic - Delta-1Glud1Glur Delta-1 Subunit |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Delta-1 antibodyAnti-Glud1 antibodyAnti-Glur Delta-1 Subunit antibodyAnti-GRID1 antibodyAnti-KIAA1220 antibody |
Information sourced from Uniprot.org
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