| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GRIA4 (254-433) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRIA4 |
| Gene ID: |
2893 |
| Uniprot ID: |
GRIA4_HUMAN |
| Immunogen Region: |
254-433 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 254-433 of human GluR4/GluA4/GluR4/GluA4/GRIA4 (NP_001070712.1). |
| Immunogen Sequence: |
HGGANVTGFQLVDFNTPMVI KLMDRWKKLDQREYPGSETP PKYTSALTYDGVLVMAETFR SLRRQKIDISRRGNAGDCLA NPAAPWGQGIDMERTLKQVR IQGLTGNVQFDHYGRRVNYT MDVFELKSTGPRKVGYWNDM DKLVLIQDVPTLGNDTAAIE NRTVVVTTIMPLMKNPILRN |
| Post Translational Modifications | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-862 by PRKCG.phosphorylation increases plasma membrane-associated GRI4 expression. |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 4Glur-4Glur4Ampa-Selective Glutamate Receptor 4Glur-DGlutamate Receptor Ionotropic - Ampa 4Glua4 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendriteInteraction With Cnih2Cnih3 And Prkcg Promotes Cell Surface Expression |
| Alternative Antibody Names | Anti-Glutamate Receptor 4 antibodyAnti-Glur-4 antibodyAnti-Glur4 antibodyAnti-Ampa-Selective Glutamate Receptor 4 antibodyAnti-Glur-D antibodyAnti-Glutamate Receptor Ionotropic - Ampa 4 antibodyAnti-Glua4 antibodyAnti-GRIA4 antibodyAnti-GLUR4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
