• Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GluR2 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from COLO205 and HUVEC cells, using GluR2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using GluR-2 Polyclonal Antibody

Anti-GRIA2 antibody (834-883 aa) (STJ93288)

SKU:
STJ93288

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Glutamate receptor 2 (834-883 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRIA2
Gene ID: 2891
Uniprot ID: GRIA2_HUMAN
Immunogen Region: 834-883 aa
Specificity: GluR-2 Polyclonal Antibody detects endogenous levels of GluR-2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GluR2 at the amino acid range 834-883
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system. It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Protein Name Glutamate Receptor 2
Glur-2
Ampa-Selective Glutamate Receptor 2
Glur-B
Glur-K2
Glutamate Receptor Ionotropic - Ampa 2
Glua2
Database Links Reactome: R-HSA-399710
Reactome: R-HSA-416993
Reactome: R-HSA-438066
Reactome: R-HSA-9022699
Reactome: R-HSA-9620244
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Postsynaptic Cell Membrane
Postsynaptic Density Membrane
Interaction With Cacng2
Cnih2 And Cnih3 Promotes Cell Surface Expression
Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons
Alternative Antibody Names Anti-Glutamate Receptor 2 antibody
Anti-Glur-2 antibody
Anti-Ampa-Selective Glutamate Receptor 2 antibody
Anti-Glur-B antibody
Anti-Glur-K2 antibody
Anti-Glutamate Receptor Ionotropic - Ampa 2 antibody
Anti-Glua2 antibody
Anti-GRIA2 antibody
Anti-GLUR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance