| Function | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2.inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. |
| Protein Name | Gremlin-1Cell Proliferation-Inducing Gene 2 ProteinCysteine Knot Superfamily 1 - Bmp Antagonist 1Dan Domain Family Member 2Down-Regulated In Mos-Transformed Cells ProteinIncreased In High Glucose Protein 2Ihg-2 |
| Database Links | Reactome: R-HSA-9830674 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Gremlin-1 antibodyAnti-Cell Proliferation-Inducing Gene 2 Protein antibodyAnti-Cysteine Knot Superfamily 1 - Bmp Antagonist 1 antibodyAnti-Dan Domain Family Member 2 antibodyAnti-Down-Regulated In Mos-Transformed Cells Protein antibodyAnti-Increased In High Glucose Protein 2 antibodyAnti-Ihg-2 antibodyAnti-GREM1 antibodyAnti-CKTSF1B1 antibodyAnti-DAND2 antibodyAnti-DRM antibodyAnti-PIG2 antibody |
Information sourced from Uniprot.org
