| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Gremlin-1 (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GREM1 |
| Gene ID: |
26585 |
| Uniprot ID: |
GREM1_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
This antibody detects endogenous levels of GREM1 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human N-ternal GREM1 |
| Function | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2.inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. |
| Protein Name | Gremlin-1Cell Proliferation-Inducing Gene 2 ProteinCysteine Knot Superfamily 1 - Bmp Antagonist 1Dan Domain Family Member 2Down-Regulated In Mos-Transformed Cells ProteinIncreased In High Glucose Protein 2Ihg-2 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Gremlin-1 antibodyAnti-Cell Proliferation-Inducing Gene 2 Protein antibodyAnti-Cysteine Knot Superfamily 1 - Bmp Antagonist 1 antibodyAnti-Dan Domain Family Member 2 antibodyAnti-Down-Regulated In Mos-Transformed Cells Protein antibodyAnti-Increased In High Glucose Protein 2 antibodyAnti-Ihg-2 antibodyAnti-GREM1 antibodyAnti-CKTSF1B1 antibodyAnti-DAND2 antibodyAnti-DRM antibodyAnti-PIG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
